SGC Frankfurt


The Structural Genomics Consortium at the Goethe University Frankfurt (SGC Frankfurt) is focused on the development of selective inhibitors (chemical probes), which help us to better understand the biological role of key signaling molecules and may serve as a starting point to target these proteins in different diseases. The SGC Frankfurt is committed to sharing its research in the spirit of Open Science.





May 2018

Stefan Knapp elected as new member of  EMBO (European Molecular Biology Organisation), joining a group of more than 1800 of the best researchers in Europe and around the world. Read more


April 2018
Open Science Probe Project launched. With this unique project, several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have entered into a pre-competitive collaboration with the SGC, to make a large number of innovative high-quality probes available to the research community  Read more




Chaikuad A, Koch P, Laufer S, Knapp S. Targeting the Protein Kinases Cysteinome. Angew Chem Int Ed Engl. 2017 Link


Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement. Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB. Cell Chem Biol. 2017 Link



Susanne Müller-Knapp
Chief Operating Officer
Tel: +49 (0) 69 798-42501
contact (at)

Max-von-Laue-Straße 15,
60438 Frankfurt am Main